To start a business in Dubai Mainland, you need to choose a business activity, determine the legal structure (such as LLC, sole proprietorship, or branch office), obtain initial approval from the Department of Economic Development (DED), draft and notarize a Memorandum of Association (MOA) if applicable, register a trade name, secure a business location, and apply for the necessary licenses and permits. It is also mandatory to have a local sponsor or service agent for certain types of businesses.